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https://hdl.handle.net/20.500.12394/7544
Título: | Pharmacogenomics of Alzheimer's and Parkinson's diseases |
Autor(es): | Cacabelos, R. |
Palabras clave: | Enfermedad de Alzheimer Enfermedad de Parkinson Farmacogenómica |
Editorial: | Universidad Continental |
Fecha de publicación: | 1-may-2020 |
Fecha disponible: | 1-jul-2020 |
Fecha de elaboración: | 2020 |
Cita bibliográfica: | Cacabelos, R. (2020). Pharmacogenomics of Alzheimer's and Parkinson's diseases. Neuroscience Letters, 726. https://doi.org/10.1016/j.neulet.2018.09.018 |
DOI: | https://doi.org/10.1016/j.neulet.2018.09.018 |
Resumen/Abstract: | Neurodegenerative disorders (NDDs)(Alzheimer’s disease, Parkinson’s disease) represent major problems of health in developed countries, with important psychosocial burden for families and high cost for the society. NDDs share some common pathogenic mechanisms such as age-related decline, multiple genetic defects distributed across the genome, deposits of abnormal proteins in the brain, and diverse environmental risk factors. Patients with NDDs currently receive polypharmacy with a high risk for drug-drug interactions and severe adverse drug events. Pharmacogenomics accounts for 60–90% variability in drug pharmacokinetics and pharmacodynamics. Major determinants of the pharmacogenomic outcome include pathogenic, mechanistic, metabolic, transporter and pleiotropic genes. The expression of these genes is under regulatory control of the epigenetic machinery. Approximately, 80% of the Caucasian population is deficient in the metabolization of drugs due to polymorphisms in metabolic genes; consequently, less than 40% of patients respond appropriately to conventional drugs. The implementation of pharmacogenomic procedures in the clinical practice may help to optimize therapeutics in NDDs. |
Notas: | Para acceder al artículo de su interés, puede solicitarlo a bibliotecariovirtual@continental.edu.pe. Por favor, comunicarse con su correo institucional |
Incluido en: | https://www.sciencedirect.com/science/article/abs/pii/S0304394018306244?via%3Dihub |
metadata.dc.format.extent: | [13] páginas |
Acceso: | Restringido |
Fuente: | Universidad Continental Repositorio Institucional - Continental |
Aparece en las colecciones: | Artículos de revisiones |
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